Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal...
This CDC developed invention identifies an assay for extremely fast and sensitive detection of Bacillus anthracis lethal toxin (LTx), the toxin responsible for the lethal effects of anthrax infection....
View ArticleDiagnostic Antigens for the Identification of Latent Tuberculosis Infection
CDC researchers have developed technology for sero-diagnosis of typically symptomless latent stage tuberculosis disease, posing a threat to individuals under immunosuppressive or anti-inflammatory...
View ArticleMonitoring the Effects of Sleep Deprivation Using Neuronal Avalanches
Investigators at the National Institute of Mental Health have discovered a novel method for monitoring the effects of sleep deprivation on brain activity. Sleep deprivation has been known to adversely...
View ArticleInhibition of HIV Infection through Chemoprophylaxis Using Emtricitabine and...
The invention is directed to prophylactic administration of emtricitabine (FTC) in combination with tenofovir or its prodrug, tenofovir disoproxil fumarate (TDF), to protect against transmission of...
View ArticleReal-time RT-PCR assay for Detection of Live Attenuated Influenza Vaccine for...
Upon intranasal vaccination, live attenuated influenza vaccine (LAIV) viruses may replicate within the nose for several days. Current clinical diagnostic tests cannot distinguish between LAIV viruses...
View ArticleRapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by...
The Zika virus (ZIKV) can be passed from a pregnant woman to her fetus. Resulting infection by this virus can cause early miscarriage and a pattern of severe birth defects in fetuses and infants....
View ArticleMonoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in...
Dengue Virus (DENV) non-structural protein 1 (NS1) is secreted in blood during the acute phase of viremic DENV infection. While there are commercially available ELISA assays for DENV NS1 detection,...
View ArticlePersonalized Cancer Evaluation (PERCEVAL) Method and Software
Cancer represents the leading cause of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths in 2012. This number is predicted to rise by...
View ArticleNovel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain...
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence...
View ArticleReal-time PCR Detection of Streptococcus pneumoniae with High Sensitivity and...
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and is also a frequent cause of bloodstream, brain and spinal cord, ear, and sinus infections. According to 2015 CDC data,...
View ArticleImmunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal...
Syphilis, a genital ulcerative disease caused by the bacterium Treponema pallidum, is associated with significant complications if left untreated. Syphilis rates in the United States have been...
View ArticleDiagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis...
Syphilis is a sexually transmitted infection that remains a global health threat. The World Health Organization estimates that more than 12 million new cases are reported in adults annually worldwide....
View ArticleHandwipe Disclosing Method for Detecting the Presence of Lead
Lead (Pb) exposure can cause serious health concerns including abdominal pain, headaches, loss of appetite, memory loss, weakness, and other symptoms. Lead residues on human skin, especially on the...
View ArticleReal-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High...
Scrub typhus is a bacterial disease caused by Orientia tsutsugamushi (O. tsutsugamushi or Ots) that is spread to people through bites of infected chiggers (larval mites). The most common symptoms can...
View ArticleReal-Time RT-PCR Detection of Rickettsia species -- PanR6/Total Nucleic Acid...
Rickettsial infections are caused by bacteria from the Rickettsia genus which are often spread by biting ticks, fleas, mites or lice. Rickettsia can cause mild to severe illness and Rickettsia species...
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